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Record W2938667012 · doi:10.1101/602516

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

2019· preprint· en· W2938667012 on OpenAlexfundno aff
Ben Brumpton, Eleanor Sanderson, Fernando Pires Hartwig, Sean Harrison, Gunnhild Åberge Vie, Yoonsu Cho, Laura D Howe, Amanda Hughes, Dorret I. Boomsma, Alexandra Havdahl, John L. Hopper, Michael C. Neale, Michel G. Nivard, Nancy L. Pedersen, Chandra A. Reynolds, Elliot M. Tucker–Drob, Andrew D. Grotzinger, Laurence J Howe, Tim Morris, Shuai Li, Wei‐Min Chen, Johan Hå‌kon Bjø‌rngaard, Kristian Hveem, Cristen J. Willer, David M. Evans, Jaakko Kaprio, Bjørn Olav Åsvol, George Davey Smith, Bjørn Olav Åsvold, Gibran Hemani, Neil M Davies

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2019
Typepreprint
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsnot available
FundersEconomic and Social Research CouncilMedical Research CouncilFakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige UniversitetNorwegian Institute of Public HealthNational Institutes of HealthFaculty of Medicine and Health, University of SydneyKarolinska InstitutetIstituto Superiore di SanitàUniversity of MelbourneUniversity of ExeterQIMR Berghofer Medical Research InstituteSt. Olavs Hospital Universitetssykehuset i TrondheimNorges ForskningsrådAcademy of FinlandStiftelsen Kristian Gerhard JebsenNorges Teknisk-Naturvitenskapelige UniversitetUniversité LavalSchool of Public Health, University of MichiganUniversidad de MurciaWellcome TrustHelse Midt-NorgeUniversity of Bristol
KeywordsMendelian randomizationAssortative matingPopulation stratificationPopulationMendelian inheritanceCausal inferenceDemographyRandomizationOffspringBiologyGeneticsEconometricsGenotypeBioinformaticsGenetic variantsClinical trialMathematicsGenePregnancySingle-nucleotide polymorphism

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.766
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.037
GPT teacher head0.290
Teacher spread0.253 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations77
Published2019
Admission routes1
Has abstractyes

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