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Record W3196449430 · doi:10.1002/9781119413936.ch2

Hierarchy of Evidence and Common Study Designs

2021· other· en· W3196449430 on OpenAlexaff
Ydo V. Kleinlugtenbelt, Kim Madden

Bibliographic record

VenueEvidence-Based Orthopedics · 2021
Typeother
Languageen
FieldDecision Sciences
TopicMeta-analysis and systematic reviews
Canadian institutionsMcMaster UniversityImpact
Fundersnot available
KeywordsObservational studyMedicineRandomized controlled trialNatural historyEvidence-based medicineIntensive care medicineSystematic reviewMedical physicsAlternative medicinePhysical therapyMEDLINESurgeryInternal medicinePathology

Abstract

fetched live from OpenAlex

The number of clinical studies in the field of orthopedics is overwhelmingly large and continually growing. There are several major types of research questions that researchers can answer. These are typically classified into therapy, prognosis, diagnosis, and economic questions. This chapter focuses on those studies addressing therapy, as this is generally the most common type of study in the orthopedic surgical literature. Randomized clinical trials (RCTs) can demonstrate the superiority of a new treatment over an existing standard treatment or a placebo, or they can demonstrate that a new treatment is noninferior to an established treatment. Well-designed RCTs can provide good measures of the effect of treatments administered under ideal conditions. Observational studies inform clinicians about disease etiology, natural history, prognostic factors, and sometimes treatment effectiveness. In most evidence hierarchies, well-designed systematic reviews and meta-analyses of level I evidence are at top of the pyramid, and expert opinion and anecdotal experience are at the bottom.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.110
metaresearch head score (Gemma)0.090
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesMetaresearch
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.719
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.1100.090
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0070.002
Bibliometrics0.0010.003
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0030.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0490.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.930
GPT teacher head0.588
Teacher spread0.342 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2021
Admission routes1
Has abstractyes

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