The mutational constraint spectrum quantified from variation in 141,456 humans
2020· article· en· Nature· Biochemistry, Genetics and Molecular Biology
aff
10 127
citations
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Integrative analysis of 111 reference human epigenomes
2015· article· en· Nature· Biochemistry, Genetics and Molecular Biology
aff
7 110
citations
Genetic effects on gene expression across human tissues
2017· article· en· Nature· Biochemistry, Genetics and Molecular Biology
aff
4 646
citations
DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors
2019· article· en· Cell Systems· Biochemistry, Genetics and Molecular Biology
fundno affsans résumé
4 592
citations
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
2021· article· en· Nature Genetics· Biochemistry, Genetics and Molecular Biology
affsans résumé
2 182
citations
Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics
2018· article· en· Nature Communications· Biochemistry, Genetics and Molecular Biology
aff
1 231
citations
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
2015· article· en· Nature· Biochemistry, Genetics and Molecular Biology
afffundsans résumé
827
citations
Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters
2015· article· en· Nature Communications· Biochemistry, Genetics and Molecular Biology
fundno aff
590
citations
Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits
2015· review· en· Cell Metabolism· Medicine
affsans résumé
486
citations
Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape
2014· article· en· Nature Biotechnology· Biochemistry, Genetics and Molecular Biology
fundno affsans résumé
478
citations
FAIR Principles: Interpretations and Implementation Considerations
2019· article· en· Data Intelligence· Computer Science
aff
459
citations
A novel community driven software for functional enrichment analysis of extracellular vesicles data
2017· article· en· Journal of Extracellular Vesicles· Biochemistry, Genetics and Molecular Biology
aff
368
citations
Whole-genome sequencing reveals host factors underlying critical COVID-19
2022· article· en· Nature· Medicine
aff
347
citations
An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance
2018· article· en· Cell· Biochemistry, Genetics and Molecular Biology
affsans résumé
332
citations
Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles
2018· article· en· Nature Communications· Biochemistry, Genetics and Molecular Biology
fundno aff
331
citations
Substrate Rigidity Regulates Human T Cell Activation and Proliferation
2012· article· en· The Journal of Immunology· Medicine
fundno aff
323
citations
Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain
2015· article· en· Neuro-Oncology· Biochemistry, Genetics and Molecular Biology
fundno aff
317
citations
The impact of rare variation on gene expression across tissues
2017· article· en· Nature· Biochemistry, Genetics and Molecular Biology
fundno aff
293
citations
Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect
2021· review· en· Nature Genetics· Medicine
afffundsans résumé
292
citations
Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study
2017· article· en· The Lancet Neurology· Biochemistry, Genetics and Molecular Biology
afffundsans résumé
289
citations
The impact of amyloid‐beta and tau on prospective cognitive decline in older individuals
2018· article· en· Annals of Neurology· Medicine
fundno aff
288
citations
How to build the virtual cell with artificial intelligence: Priorities and opportunities
2024· article· en· Cell· Biochemistry, Genetics and Molecular Biology
aff
284
citations
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
2018· review· en· Nature Communications· Medicine
aff
280
citations
The National Center for Biomedical Ontology
2011· article· en· Journal of the American Medical Informatics Association· Biochemistry, Genetics and Molecular Biology
aff
280
citations
High-content CRISPR screening
2022· article· en· Nature Reviews Methods Primers· Biochemistry, Genetics and Molecular Biology
afffundsans résumé
253
citations